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RESTORING IMMUNE HOMEOSTASIS

TO ENHANCE PATIENT CARE

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Virtual KOL Event Replay

'1104: A First-in-Class Peptide for Eosinophilic Esophagitis (EoE) and Allergic Disease

Recorded on Tuesday, August 29, 2023

About

We are advancing patient focused revolutionary treatments for serious allergic and autoimmune diseases.

We are a revolutionary biotherapeutics company and our mission is to revolutionize patient care with therapies that are more effective, safer and allow for easier routes of administration than current options. 

How?

By advancing therapies that restore immune homeostasis, targeting the immune system upstream. They offer a unique mechanism through impact on both the regulatory and effector arms. On the regulatory side, they upregulate T and B regulatory cells. On the effector side, they downregulate effector T cells. This upstream, disease-agnostic and dual action approach results in a rapid and prolonged effect without broad immune suppression. They also have potential to offer dosing optionality through subcutaneous and sublingual routes, based on preclinical research, offering a highly competitive profile with potential to disrupt the current treatment landscape as potential first line therapies.

Why?

Existing therapies for allergic and autoimmune diseases address the problem downstream, once the inflammation has occurred. They only address limited aspects of the immune response with most failing to engage the regulatory component. As a result, these treatments require frequent chronic dosing, provide only short-term disease remission in a limited number of patients and suppress the immune system, ultimately putting patients at risk of developing serious infections and life-threatening side effects.

Pipeline

Pipeline

Our two platform drug candidates, ‘1104 and ‘1805, have demonstrated favorable safety profile across five Phase 1-2 studies without immune suppression, and initial translation into clinical response in Phase 2 trials. Preclinical studies have further demonstrated optionality in the route of administration through potential subcutaneous and sublingual delivery of ‘1104. Given our disease-agnostic approach, we are uniquely positioned as revolutionaries in the development of drugs for multiple allergic and immune-mediated diseases.

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news

Latest News

October 21, 2024 | Press Release

Revolo Shares New Preclinical Data Showcasing the Potential of Sublingual ‘1104 in Allergic Disease

September 18, 2024 | Press Release

Revolo Announces New Preclinical Data Further Validating Atopic Dermatitis as a Target Indication for ‘1104

Investors

Revolo Biotherapeutics is a privately held, venture-funded biotechnology firm engaged in the development of revolutionary patient focused therapies. If you’d like to get more information, don’t hesitate to contact us!

Partnerships

We are open to engaging interested parties for partnering discussions

Contact Us

Interested in learning more about our approach?

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Jorge De Alba, ph.d.

Vice President, Discovery and Translational Science

Dr Jorge De Alba is an accomplished scientist that brings over 25 years of experience in drug discovery successfully leading preclinical and translational research in the immunology and inflammation space across different biopharmaceutical organizations.

Paul Eggleton, ph.d.

Vice President, Immunology

Professor Paul Eggleton has 30 years of experience working on the immune regulatory function of chaperone proteins in autoimmune, neurodegenerative and inflammatory diseases.  He has work extensively in the field of immunopathology in North America and Europe in medical institutions and the pharmaceutical industry.

Maria Pittaras, pmp

Vice President, Portfolio and Program Management

Maria has over 25 years of experience in the biopharmaceutical industry. She has a successful track record of new product planning, as well as facilitation of cross-functional, high-performing project teams across all phases of drug development from preclinical through commercialization.

David Southwell

Chairman

In addition to his role as Chairman of Revolo, David Southwell serves on the Board of Directors for Rocket Pharmaceuticals and PTC Therapeutics. David is the former CEO of TScan Therapeutics. Before that, he served as President and CEO of Inotek Pharmaceuticals until its merger with Rocket Pharmaceuticals in 2018. David has held other senior leadership roles and Board of Director positions at companies including Human Genome Sciences, Sepracor, Spero Therapeutics, inVentiv Health, and THL Credit.

Kari Brown, M.D.

Chief Medical Officer

Kari Brown, a board-certified allergist and immunologist, brings 10 years of experience in clinical treatment deployment, development and strategy to Revolo. In her various roles, Kari has played an integral part in advancing pipelines across allergy and immunology disease indications.

Femi Oluboyede

Vice President, Technical Operations, CMC

Femi Oluboyede has over 20 years of experience within the bio-pharma industry, with a proven track record of achieving strategic corporate objectives. Through his roles, Femi has excelled in fostering alignment across functional teams, including Process Development, Tech-transfers, cGMP Manufacturing in Biologics, Small molecules, Proteins and Synthetic Peptides. He has succeeded in delivering investigational products and providing support across different phases of clinical trials.

Tunde Otulana, M.D.

Non-Executive Director

Tunde is currently the Chief Medical Officer of Veloxis Pharmaceuticals in North Carolina, USA since August 2020. Prior to Veloxis he was Senior Vice President and Chief Medical Officer at Mallinckrodt Pharmaceuticals. His career, which spans about 30 years in industry, government and academia, includes leadership roles at Boehringer Ingelheim Pharmaceutical Inc. and the US Food and Drug Administration (“FDA”). Tunde is a physician trained in Pulmonary and Critical Care Medicine.

Beth Alley

Senior Vice President, Regulatory Affairs and Pipeline Planning

Beth Alley has over 20 years of experience within the biopharmaceutical industry in regulatory affairs, commercial strategy, and medical writing throughout all phases of drug development. Her primary areas of focus have been in development of biologics for treatment of autoimmune, inflammatory, and infectious diseases.

Glen Giovanetti

Non-Executive Director

Glen Giovanetti has more than 35 years of experience in strategy and operational leadership in the life science industry as well as in financial governance, risk and reporting as EY’s Global Biotechnology Sector Leader and Life Sciences Sector Leader. He currently serves on the Board of Directors of Life Science Cares, Teon Therapeutics and XW Pharma.

Marla S. Persky

Non-Executive Director

Marla S. Persky currently serves as the chief executive officer and president of WOMN LLC. She has more than 25 years of international senior business and legal experience in the pharmaceutical industry having held numerous business and legal positions at Boehringer Ingelheim and Baxter International. She currently serves on the Boards of Directors of Xeris Pharmaceuticals, YGEIA Consulting Group, Primary Stages, World Neighbors and A Better Chance in Ridgefield.

Dora Rau

Senior Vice President, Quality

Dora Rau brings 25 years of experience in development and commercial operations for drugs, biologics, devices and combination products to the team. She has held numerous executive-level quality positions, with expertise in building quality systems and in leading teams to attain successful regulatory authority inspection outcomes and product approvals.

Jonathan Gold

Chief Financial Officer

Over the last 25 years, Jonathan Gold has been an institutional venture capitalist, a public fund manager, a founder, an operating executive, and a board member for companies across sectors including life sciences. In those roles, he was active in the development, financing and mergers and acquisitions for numerous public and private companies.

Michael Albisser

Non-Executive Director​

Michael is a partner of Metellus, a Zurich and London-based venture capital firm investing in technology and life sciences with ground-breaking potential. Having more than 25 years of experience in the finance area he is responsible for finance, tax, and deal structures. He serves on the board of various venture-backed companies.

Dr. Isaac Cheng, m.d.

Non-Executive Director

Dr. Isaac Cheng is currently an investment professional at Morningside, a venture capital and private equity institution based in Boston USA, and Shanghai China. Dr. Cheng focuses primarily on biopharmaceutical and healthcare investments. He has served on numerous public and private company boards.

Peter Greenleaf

Non-Executive Director

Peter Greenleaf currently serves as the chief executive officer (CEO) and member of the Board of Directors of Aurinia, (NASDAQ: AUPH / TSX: AUP), an autoimmune therapeutics company. He has held several other CEO and chairman roles. He is also currently a member of the Board of Directors of Antares Pharmaceuticals, Inc. (NASDAQ: ATRS) and Chairman of the Board of Directors of Biodelivery Sciences International, Inc. (NASDAQ: BDSI).

Marylyn Rigby

SVP of Marketing and Investor Relations

Marylyn Rigby is an experienced pharmaceutical, biotech, and drug delivery professional. In addition to her expertise in marketing, public and investor relations, she has a successful track record with business development, licensing, public and private equity financing, strategy and other key corporate functions.

Nancy Vinh

SVP of Clinical Operations

Nancy Vinh brings over 20 years of experience in managing early and late phase, international clinical trials for drugs, biologics, cell therapy and combination products across a wide range of therapeutic areas to the team. She has served as head of clinical operations and led registrational and label expansion trials execution.

Team Members

Dr. Clare Burgess

Chief Development Officer

Dr. Clare Burgess has 24 years of experience in clinical drug development as a pharmacologist and has worked across a wide range of therapeutic areas within the pharmaceutical industry. She has held multiple leadership roles and has led multidisciplinary teams across the world.

Jeff Myers, m.d., ph.d

Chief Medical Officer

Jeff Myers, M.D., Ph.D., has 20 years of experience in medical affairs, regulatory and clinical development within the biopharmaceutical industry, with focuses on cardiovascular, pulmonary, oncology, and inflammatory diseases.

Before entering the industry, he practiced as a congenital cardiac surgeon and served as the chief of pediatric cardiac surgery at Massachusetts General Hospital and as Associate Professor of Surgery at Harvard Medical School.

Team Members

Dr. Roly Foulkes

Chief Scientific Officer

A true drug discoverer, Dr. Roly Foulkes has 25 years of experience building and delivering innovative therapeutic portfolios within the immunology and inflammatory disease space. He has a strong record advising small and medium sized immunology biopharma companies in developing competitive therapeutic strategies and bringing new innovative molecules to the clinic.

Jones w (woody) Bryan, ph.d.

President & Chief Executive Officer

Jones (Woody) Bryan, Ph.D., brings almost 30 years of experience in the healthcare industry to the team, having led successful business development operations in both private and public pharma and biotech companies.

Jonathan Rigby, mba

Group Chief Executive Officer

As employee #1 of Revolo Biotherapeutics in the US, Jonathan Rigby has led the company through substantial and rapid growth. He brings three decades of experience creating value and opportunities for companies in the pharmaceutical, biotech and drug delivery technology industry.

Team Members