RESTORING IMMUNE HOMEOSTASIS
TO ENHANCE PATIENT CARE
Virtual KOL Event Replay
'1104: A First-in-Class Peptide for Eosinophilic Esophagitis (EoE) and Allergic Disease
Recorded on Tuesday, August 29, 2023
About
We are advancing patient focused revolutionary treatments for serious allergic and autoimmune diseases.
We are a revolutionary biotherapeutics company and our mission is to revolutionize patient care with therapies that are more effective, safer and allow for easier routes of administration than current options.
How?
By advancing therapies that restore immune homeostasis, targeting the immune system upstream. They offer a unique mechanism through impact on both the regulatory and effector arms. On the regulatory side, they upregulate T and B regulatory cells. On the effector side, they downregulate effector T cells. This upstream, disease-agnostic and dual action approach results in a rapid and prolonged effect without broad immune suppression. They also have potential to offer dosing optionality through subcutaneous and sublingual routes, based on preclinical research, offering a highly competitive profile with potential to disrupt the current treatment landscape as potential first line therapies.
Why?
Existing therapies for allergic and autoimmune diseases address the problem downstream, once the inflammation has occurred. They only address limited aspects of the immune response with most failing to engage the regulatory component. As a result, these treatments require frequent chronic dosing, provide only short-term disease remission in a limited number of patients and suppress the immune system, ultimately putting patients at risk of developing serious infections and life-threatening side effects.
Pipeline
Pipeline
Our two platform drug candidates, ‘1104 and ‘1805, have demonstrated favorable safety profile across five Phase 1-2 studies without immune suppression, and initial translation into clinical response in Phase 2 trials. Preclinical studies have further demonstrated optionality in the route of administration through potential subcutaneous and sublingual delivery of ‘1104. Given our disease-agnostic approach, we are uniquely positioned as revolutionaries in the development of drugs for multiple allergic and immune-mediated diseases.
news
Latest News
Investors
Revolo Biotherapeutics is a privately held, venture-funded biotechnology firm engaged in the development of revolutionary patient focused therapies. If you’d like to get more information, don’t hesitate to contact us!